<p>The emerging technique of GPS Radio Occultation has been used to detect the ionospheric irregularities prominent in the F-region known as equatorial plasma bubbles. The plasma bubbles are characterized by depreciated regions of electron density. For investigating the plasma bubbles, a nine-year (2008–2016) long time series of signal-to-noise ratio data are used from the vertical GPS radio occultation profiles. The variation in the signal-to-noise ratio of the GPS signals can be linked to vertical changes in the electron density profiles that mainly occur in line with the irregularities in the Earth's ionosphere. The analysis revealed that the F-region irregularities, associated with plasma bubbles occur mainly post sunset close to Earth's geomagnetic equator. Dependence on the solar cycle as well as distinctive seasonal variation is observed when analyzed for different years. In contrast to the other ionospheric remote sensing methods, GPS Radio Occultation technique uniquely personifies the activity of the plasma bubbles based on altitude resolution on a global scale.</p>